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Can I read Molecular epidemiology of hepatitis B virus in Dakar, Sénégal on EtoBox?
Molecular epidemiology of hepatitis B virus in Dakar, Sénégal by Muriel Vray; Jean-Marc Debonne; Jean-Marie Sire; Nathalie Tran; Benoit Chevalier; Jean-Christophe Plantier; Fatou Fall; Guy Vernet; François Simon; Papa Saliou Mb is a Medicine article available to read on EtoBox.
What is Molecular epidemiology of hepatitis B virus in Dakar, Sénégal about?
Using DNA chip technology and real-time quantitative PCR, molecular profile of HBV strains infecting blood donors and patients in Dakar, Se ́ne ́gal was studied. All HBsAg-positive blood donors (n 1⁄4 175) and all patients who presented with chronic hepatitis B (n 1⁄4 29) between 1st June 2003 and 31st July 2003 were studied. One patient, a blood donor, was coinfected by HCV, and nine patients had anti-HDV antibodies. Few persons in either group were HBeAg-positive. Viral load values were relatively low but correlated with biochemical abnormalities. Patients were infected mainly by genotype E (72%). Patients infected by genotype A (28%) tended to be younger than other patients. There was no significant difference between the blood donors and the patients with hepatitis B as regards virological markers, including viral load, when the HBV genotype was taken into account. The BCP A1762T and G1764A mutations were found in four patients and one patient, respectively; the two mutations were never found in the same patient. The W28\* mutation at position 1896 of the core was detected in 19 of the 32 genotyped patients, 18 (83%) of whom had genotype E infection. ALT levels were not influ
Who reads Molecular epidemiology of hepatitis B virus in Dakar, Sénégal?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Muriel Vray; Jean-Marc Debonne; Jean-Marie Sire; Nathalie Tran; Benoit Chevalier; Jean-Christophe Plantier; Fatou Fall; Guy Vernet; François Simon; Papa Saliou Mb
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)