Can I read Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications on EtoBox?

Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications by Devendra Singh; Himika Wasan; K.H. Reeta is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications about?

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to infect hundred thousands of people every day worldwide. Since it is a novel virus, research continues to update the possible therapeutic targets when new evidence regarding COVID-19 are gathered. This article presents an evidence-based hypothesis that activating the heme oxygenase-1 (HO-1) pathway is a potential target for COVID-19. Interferons (IFNs) have broad-spectrum antiviral activity including against SARS-CoV-2. Induction of HO-1 and increase in the heme catabolism end-product confer antiviral activity. IFN activation results in inhibition of viral replication in various viral infections. COVID-19 induced inflammation as well as acute respiratory distress syndrome (ARDS), and coagulopathies are now known major causes of mortality. A protective role of HO-1 induction in inflammation, inflammation-induced coagulation, and ARDS has been reported. Based on an association of HO-1 promoter polymorphisms and disease severity, we propose an evaluation of the status of these polymorphisms in COVID-19 patients who become severely ill. If an association is established

Who reads Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications?

Author

Devendra Singh; Himika Wasan; K.H. Reeta

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0891-5849)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)