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Can I read Prolonged Cold-preservation of Nerve Allografts on EtoBox?
Prolonged Cold-preservation of Nerve Allografts by Ida K. Fox; Andrs Jaramillo; Daniel A. Hunter; Susan R. Rickman; Thalachallour Mohanakumar; Susan E. Mackinnon is a Medicine article available to read on EtoBox.
What is Prolonged Cold-preservation of Nerve Allografts about?
The goal of this study was to determine the effect of varying durations of cold-preservation on the immunogenicity of nerve allografts and their subsequent ability to facilitate neuroregeneration across a short nerve gap. Allografts preserved for 1, 4, and 7 weeks were compared to untreated allografts and isografts. There was a shift from an interferon-␥-producing cellular response (untreated allografts) to an absence of response (7-week cold-preserved allografts and isografts). There were no detectable alloantibodies by flow cytometry. Histomorphometry distal to the graft showed robust regeneration in the isograft and 7-week cold-preserved groups when compared to the untreated allograft group. Increasing duration of coldpreservation diminished the cellular immune response. This cold-preservation does not preclude subsequent nerve regeneration across a short nerve graft. Prolonged cold-preservation of nerve allograft tissue could serve as a means to produce unlimited graft material for use in peripheral nerve reconstruction.
Who reads Prolonged Cold-preservation of Nerve Allografts?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ida K. Fox; Andrs Jaramillo; Daniel A. Hunter; Susan R. Rickman; Thalachallour Mohanakumar; Susan E. Mackinnon
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)