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An algorithm combining procalcitonin and lung ultrasound improves the diagnosis of bacterial pneumonia in critically ill children: The PROLUSP study, a randomized clinical trial by Carmina Guitart; Javier Rodríguez‐Fanjul; Sara Bobillo‐Perez; José L. Carrasco; Emilio J. Inarejos Clemente; Francisco J. Cambra; Mònica Balaguer; Iolanda Jordan is a Medicine article available to read on EtoBox.
What is An algorithm combining procalcitonin and lung ultrasound improves the diagnosis of bacterial pneumonia in critically ill children: The PROLUSP study, a randomized clinical trial about?
## Abstract ## Background Lung ultrasound (LUS) and procalcitonin (PCT) are independently used to improve accuracy when diagnosing lung infections. The aim of the study was to evaluate the accuracy of a new algorithm combining LUS and PCT for the diagnosis of bacterial pneumonia. ## Methods Randomized, blinded, comparative effectiveness clinical trial. Children <18 years old with suspected pneumonia admitted to pediatric intensive care unit were included, and randomized into experimental group (EG) or control group (CG) if LUS or chest X‐Ray (CXR) were done as the first pulmonary image, respectively. PCT was determined. In patients with bacterial pneumonia, sensitivity, specificity, and predictive values of LUS, CXR, and of both combined with PCT were analyzed and compared. Concordance between the final diagnosis and the diagnosis concluded through the imaging test was assessed. ## Results A total of 194 children, with a median age of 134 (interquartile range [IQR]: 39–554) days, were enrolled, 96 randomized into the EG and 98 into the CG. Bacterial pneumonia was diagnosed in 97 patients. Sensitivity and specificity for bacterial pneumonia diagnosis were 78% (95% confidence interva
Who reads An algorithm combining procalcitonin and lung ultrasound improves the diagnosis of bacterial pneumonia in critically ill children: The PROLUSP study, a randomized clinical trial?
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- Author
- Carmina Guitart; Javier Rodríguez‐Fanjul; Sara Bobillo‐Perez; José L. Carrasco; Emilio J. Inarejos Clemente; Francisco J. Cambra; Mònica Balaguer; Iolanda Jordan
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)