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Application of cinnamic acid in the structural modification of natural products: A review by Hao Deng; Qian Xu; Hong-Yan Guo; Xing Huang; Fener Chen; Lili Jin; Zhe-Shan Quan; Qing-Kun Shen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Application of cinnamic acid in the structural modification of natural products: A review about?

Natural products can generally exhibit a variety of biological activities, but most show mediocre performance in preliminary activity evaluation. Natural products often require structural modification to obtain promising lead compounds. Cinnamic acid (CA) is readily available and has diverse biological activities and low cytotoxicity. Introducing CA into natural products may improve their performance, enhance biological activity, and reduce toxic side effect. Herein, we aimed to discuss related applications of CA in the structural modification of natural products and provide a theoretical basis for future derivatization and drug development of natural products. Published articles, web databases (PubMed, Science Direct, SCI Finder, and CNKI), and clinical trial websites (https://clinicaltrials.gov/) related to natural products and CA derivatives were included in the discussion. Based on the inclusion criteria, 128 studies were selected and discussed herein. Screening natural products of CA derivatives allowed for classification by their biological activities. The full text is organized according to the biological activities of the derivatives, with the following categories: anti-tum

Who reads Application of cinnamic acid in the structural modification of natural products: A review?

Author

Hao Deng; Qian Xu; Hong-Yan Guo; Xing Huang; Fener Chen; Lili Jin; Zhe-Shan Quan; Qing-Kun Shen

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)