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In Vivo Imaging of Prostate Cancer Involving Bone in a Mouse Model by Vikas Kundra; Chaan S. Ng; Jingfei Ma; James A. Bankson; Roger E. Price; Dianna D. Cody; Kim-Anh Do; Lin Han; Nora M. Navone is a Medicine article available to read on EtoBox.

What is In Vivo Imaging of Prostate Cancer Involving Bone in a Mouse Model about?

## Abstract ## Background We compared the abilities of clinically relevant imaging modalities to quantify prostate cancer involving bone in a mouse model. Such non‐invasive methods are needed pre‐clinically to understand tumor biology and to evaluate therapy. ## Methods Human prostate cancer cells (MDA PCa 2b) or vehicle were injected into the right or left femur of SCID mice (n = 8). Radiography, computed tomography, and magnetic resonance imaging were performed 5 and 8 weeks later (n = 7). Bone scintigraphy (n = 6) was also performed at week 8. Imaging findings were compared with histology and correlated with contemporaneous serum prostate‐specific antigen levels. ## Results Among the modalities evaluated, only MR imaging delineated prostate tumors involving bone. Tumor volume assessed by MR imaging correlated with PSA levels (R^2^ = 0.87, __P__ < 0.001). MR imaging of tumors corresponded with histology. Imaging of mineralized bone by CT corresponded with histology. ## Conclusion In a mouse model, prostate tumors involving bone can be quantified using MR imaging. Prostate 67:50–60, 2007. © 2006 Wiley‐Liss, Inc.

Who reads In Vivo Imaging of Prostate Cancer Involving Bone in a Mouse Model?

Author

Vikas Kundra; Chaan S. Ng; Jingfei Ma; James A. Bankson; Roger E. Price; Dianna D. Cody; Kim-Anh Do; Lin Han; Nora M. Navone

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2006

Language

EN

Field

Medicine (Health Sciences)