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Selective induction of Fos and FRA immunoreactivity within the mesolimbic and mesostriatal dopamine terminal fields by Roger P. Dilts Jr.; Todd E. Helton; Jaqueline F. McGinty is a Neuroscience article available to read on EtoBox.

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## Abstract The influence of the mesencephalic dopaminergic projections on the neurons within the basal forebrain and prefrontal cortex is not well understood although it has been intensely investigated. The purpose of this study was to evaluate the expression of Fos‐like and FRA‐like (Fos Related Antigens) immunoreactivity (IR) as a qualitative and quantitative marker of neuronal activity within the mesolimbic and mesostriatal dopamine terminal fields. Following the administration of apomorphine (5.0 mg/kg S.C.), a rapid increase in FRA‐IR, accompanied by Fos‐IR, was observed within the striatum in a patchy distribution. Apomorphine also induced the expression of FRA‐IR within the nucleus accumbens, cortex, septum, and the islands of Calleja complex. This broad pattern of activation contrasts with the limited expression of Fos‐IR and FRA‐IR within the dorsolateral striatum, dorsomedial shell of the nucleus accumbens, and cingulate cortex following haloperidol administration (2.0 mg/kg, S.C.). Finally, it was observed that nuclei expressed Fos‐IR rapidly and transiently within the striatum following haloperidol, whereas the number of FRA‐IR nuclei remained elevated but changed in d

Who reads Selective induction of Fos and FRA immunoreactivity within the mesolimbic and mesostriatal dopamine terminal fields?

Author

Roger P. Dilts Jr.; Todd E. Helton; Jaqueline F. McGinty

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1993

Language

EN

Field

Neuroscience (Life Sciences)