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The Role of Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury by Gagandeep Singh-Mallah; Syam Nair; Mats Sandberg; Carina Mallard; Henrik Hagberg is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Role of Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury about?

Perinatal brain injury is caused by hypoxia-ischemia (HI) in term neonates, perinatal arterial stroke, and infection/inflammation leading to devastating long-term neurodevelopmental deficits. Therapeutic hypothermia is the only currently available treatment but is not successful in more than 50% of term neonates suffering from hypoxic-ischemic encephalopathy. Thus, there is an urgent unmet need for alternative or adjunct therapies. Reactive oxygen species (ROS) are important for physiological signaling, however, their overproduction/accumulation from mitochondria and endoplasmic reticulum (ER) during HI aggravate cell death. Mechanisms underlying ER stress-associated ROS production have been primarily elucidated using either non-neuronal cells or adult neurodegenerative experimental models. Findings from mature brain cannot be simply transferred to the immature brain. Therefore, age-specific studies investigating ER stress modulators may help investigate ER stress-associated ROS pathways in the immature brain. New therapeutics such as mitochondrial site-specific ROS inhibitors that selectively inhibit superoxide (O)/hydrogen peroxide (HO) production are currently being developed. B

Who reads The Role of Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury?

Author

Gagandeep Singh-Mallah; Syam Nair; Mats Sandberg; Carina Mallard; Henrik Hagberg

Publisher

Mary Ann Liebert; Mary Ann Liebert Inc.; Mary Ann Liebert Inc (ISSN 1523-0864)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)