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Sonodynamic Cytokine Nanocomplexes with Specific Stimulation towards Effector T Cell for Combination Cancer Immunotherapy by Mengke Xu; Jie Yu; Chi Zhang; Cheng Xu; Xin Wei; Kanyi Pu is a Chemistry article available to read on EtoBox.

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## Abstract Cytokine therapy mediates the interaction between immune cells and non‐immune cells in the tumor microenvironment (TME), forming a promising approach in cancer therapy. However, the dose‐dependent adverse effects and non‐selective stimulation of cytokines limit their clinical use. We herein report a sonodynamic cytokine nano‐immunocomplex (SPN~AI~) that specifically activates effector T cells (Teffs) for antitumor immunotherapy. By conjugating anti‐interleukin‐2 (anti‐IL‐2) antibodies S4B6 on the semiconducting polymer nanoparticles to afford SPN~A~, this nanoantibody SPN~A~ can bind with IL‐2 to form SPN~AI~ which can block the interaction between IL‐2 and regulatory T cells (Tregs), selectively activating Teffs in TME. Moreover, SPN~AI~ generates ^1^O~2~ to trigger immunogenic cell death of cancer cells upon sono‐irradiation, which promotes the maturation of dendritic cells and the proliferation of Teffs. This SPN~AI~‐mediated combination sonodynamic immunotherapy thus elevates the ratio of Teffs/Tregs in TME, resulting in inhibition of tumor growth, suppression of lung metastasis and prevention of tumor relapse.

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Author

Mengke Xu; Jie Yu; Chi Zhang; Cheng Xu; Xin Wei; Kanyi Pu

Publisher

Wiley

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)