Can I read Overcorrection and Undercorrection with Fixed Dosing of Bolus Hypertonic Saline for Symptomatic Hyponatremia on EtoBox?

Overcorrection and Undercorrection with Fixed Dosing of Bolus Hypertonic Saline for Symptomatic Hyponatremia by Anissa Pelouto; Julie C Refardt; Mirjam Christ-Crain; Adrienne A M Zandbergen; Ewout J Hoorn is a Medicine article available to read on EtoBox.

What is Overcorrection and Undercorrection with Fixed Dosing of Bolus Hypertonic Saline for Symptomatic Hyponatremia about?

Abstract Objective Current guidelines recommend treating symptomatic hyponatremia with rapid bolus-wise infusion of fixed volumes hypertonic saline regardless of body weight. We hypothesize that this approach is associated with overcorrection and undercorrection in patients with low and high body weight. Design Single-center, retrospective cohort study. Methods Data were collected on patients treated with ≥ 1 bolus 100 or 150 mL 3% NaCl for symptomatic hyponatremia between 2017–2021. Outcomes were overcorrection (plasma sodium rise >10 mmol/L/24 h, > 18 mmol/L/48 h or relowering therapy) and undercorrection (plasma sodium rise < 5 mmol/L/24 h). Low and high body weight were defined according to lowest (≤ 60 kg) and highest (≥ 80 kg) quartiles. Results Hypertonic saline was administered to 180 patients and caused plasma sodium to rise from 120 mmol/L to 126.4 mmol/L (24 h) and 130.4 mmol/L (48 h). Overcorrection occurred in 32 patients (18%) and was independently associated with lower body weight, weight ≤ 60 kg, lower baseline plasma sodium, volume depletion, hypokalemia and less boluses. In patients without rapidly reversible causes of hyponatremia, overcorrection still occurred

Who reads Overcorrection and Undercorrection with Fixed Dosing of Bolus Hypertonic Saline for Symptomatic Hyponatremia?

Author

Anissa Pelouto; Julie C Refardt; Mirjam Christ-Crain; Adrienne A M Zandbergen; Ewout J Hoorn

Publisher

Oxford University Press (OUP)

Published

2023

Language

EN

Field

Medicine (Health Sciences)