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Cycloaddition Across The Benzofuran Ring As An Approach To The Morphine Alkaloids by Brandon Timm is a document available to read on EtoBox.

The document discusses using an intramolecular Diels-Alder reaction of amidofurans tethered to a benzofuran ring as an approach to synthesizing morphine alkaloids. Bromo substitution on the furan ring did not activate it enough for cycloaddition across the aromatic benzofuran. However, a large o-methylbenzyl group on the amido nitrogen causes the reactive s-trans conformation and facilitates cycloaddition across a tethered benzofuran.

Author

Brandon Timm

Language

EN