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Synthesis, Characterization of Calcium Phosphates/polyurethane Composites for Weight‐bearing Implants by Toshitaka Yoshii; Jerald E. Dumas; Atsushi Okawa; Dan M. Spengler; Scott A. Guelcher is a Medicine article available to read on EtoBox.
What is Synthesis, Characterization of Calcium Phosphates/polyurethane Composites for Weight‐bearing Implants about?
## Abstract Calcium phosphate (CaP)/polymer composites have been studied as an alternative graft material for the treatment of bone defects. In this study, lysine‐triisocyanate‐based polyurethane (PUR) composites were synthesized from both hydroxyapatite (HA) and β‐tricalcium phosphate (TCP) to reduce the brittleness of CaP and increase the bioactivity of the polymer. The mechanical properties and __in vitro__ cellular response were investigated for both HA/PUR and TCP/PUR composites. The composites were implanted in femoral defects in rats, and __in vivo__ bioactivity was evaluated by X‐rays, micro‐computed tomography (μCT), and histological sections. In biomechanical testing, PUR improved the mechanical properties of the CaP, thus rendering it potentially suitable for weight‐bearing applications. __In vitro__ cell culture studies showed that CaP/PUR composites are biocompatible, with β‐TCP enhancing the cell viability and proliferation relative to HA. CaP/PUR composites also supported the differentiation of osteoblastic cells on the materials. When implanted in rat femoral defects, the CaP/PUR composites were biocompatible and osteoconductive with no adverse inflammatory response
Who reads Synthesis, Characterization of Calcium Phosphates/polyurethane Composites for Weight‐bearing Implants?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Toshitaka Yoshii; Jerald E. Dumas; Atsushi Okawa; Dan M. Spengler; Scott A. Guelcher
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)