About this Biochemistry, Genetics and Molecular Biology article
Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. by C. Selvam; Sanjay M. Jachak; K. K. Bhutani is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
## Abstract The ethyl acetate extract of stem bark of __Semecarpus anacardium__ showing __in vivo__ anti‐inflammatory activity in carrageenan induced rat paw edema assay was investigated in order to identify its active compounds. Chemical investigation of the ethyl acetate extract of __S.anacardium__ afforded 3,4,2′,4′‐tetrahydroxychalcone (butein) and 7,3′,4′‐trihydroxyflavone. Evaluation of COX‐1 inhibitory activity of 3,4,2′,4′‐tetrahydroxychalcone and 7,3′,4′‐trihydroxyflavone provided the IC~50~ values of 28.4 and 36.7 μM respectively. Further investigation of these compounds for COX‐2 inhibitory activity revealed moderate potency towards this enzyme. Copyright © 2004 John Wiley & Sons, Ltd.
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- Author
- C. Selvam; Sanjay M. Jachak; K. K. Bhutani
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)