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Evaluating exercise challenge to validate cardiac autonomic dysfunction in lean PCOS phenotype by Abha Mishra; Renuka Sharma; Pratima Mittal; Raj Kapoor; Shival Srivastav is a Medicine article available to read on EtoBox.

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## Abstract ## Background Polycystic ovary syndrome (PCOS) is frequently associated with infertility, obesity, hypertension, and diabetes mellitus. Cardiac autonomic dysfunction is well documented in long-term patients of PCOS, with impairment being proportionate to disease duration. However, there is paucity of literature on cardiac autonomic tone in the “lean” phenotype of PCOS. We used exercise challenge to probe for autonomic dysfunction, as assessed by heart rate variability (HRV), an index of cardiac autonomic tone. ## Methods Our study population consisted of 27 newly diagnosed PCOS patients and 25 healthy females matched by age and body mass index. Short-term HRV was assessed using time and frequency domain indices. Moderate, isotonic exercise was used as an interventional tool. Indices of both groups were compared in three bins – at baseline, immediate, and late postexercise stages. ## Results The groups had comparable HRV indices at baseline. However, low-frequency (LF) power was significantly reduced in PCOS patients during immediate and late postexercise phases when compared with controls (p = 0.03 and 0.03, respectively). Time domain indices also exhibited a fall poste

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Author

Abha Mishra; Renuka Sharma; Pratima Mittal; Raj Kapoor; Shival Srivastav

Publisher

Walter de Gruyter GmbH

Published

2019

Language

EN

Field

Medicine (Life Sciences)