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Late gadolinium enhancement in Brugada syndrome: A marker for subtle underlying cardiomyopathy? by Rachel Bastiaenen; Andrew T. Cox; Silvia Castelletti; Yanushi D. Wijeyeratne; Nicholas Colbeck; Nadia Pakroo; Hammad Ahmed; Nick Bunce; Lisa Anderson; James C. Moon; Sanjay Prasad; Sanjay Sharma; Elijah R. Behr is a Medicine article available to read on EtoBox.

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## Background: There is increasing evidence that the brugada ecg pattern is a marker of subtle structural heart disease. ## Objective: The purpose of this study was to characterize patients with brugada syndrome (brs) using cardiovascular magnetic resonance (cmr) with late gadolinium enhancement (lge). ## Methods: Brs was diagnosed according to international guidelines. twenty-six percent of patients with brs carried scn5a mutations. cmr data from 78 patients with brs were compared with 78 healthy controls (44 ± 15 vs 42 ± 14 years; p = .434; and 64% vs 64% male; p = 1). ## Results: Right ventricular (rv) ejection fraction was slightly lower (61 ± 8% vs 64 ± 5%; p = .004) and rv end-systolic volume slightly greater (31 ± 10 ml/m vs 28 ± 6 ml/m; p = .038) in brs compared with controls. these values remained within the normal range. lge was demonstrated in 8% of patients with brs (left ventricular midwall lge in 5%) but not in controls (p = .028). in patients with brs with midwall lge there were no other features of cardiomyopathy at the time of cmr, but genetic testing and follow-up revealed a desmoplakin mutation in 1 patient and evolution of t-wave inversion throughout all precord

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Author

Rachel Bastiaenen; Andrew T. Cox; Silvia Castelletti; Yanushi D. Wijeyeratne; Nicholas Colbeck; Nadia Pakroo; Hammad Ahmed; Nick Bunce; Lisa Anderson; James C. Moon; Sanjay Prasad; Sanjay Sharma; Elijah R. Behr

Publisher

Elsevier BV

Published

2016

Language

EN

Field

Medicine (Health Sciences)