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Can I read Effect of Microneedles Shape on Skin Penetration and Transdermal Drug Administration on EtoBox?
Effect of Microneedles Shape on Skin Penetration and Transdermal Drug Administration by Selene De Martino; Mario Battisti; Francesco Napolitano; Antonio Palladino; Luigia Serpico; Eugenio Amendola; Alfonso Martone; Paolo De Girolamo; Antonino Squillace; Principia Dardano; Luca De Stefano; Stefania Dello Iacono is a Engineering article available to read on EtoBox.
What is Effect of Microneedles Shape on Skin Penetration and Transdermal Drug Administration about?
Microneedle (MN) patches are highly efficient and versatile tools for transdermal drug administration, in particular for pain-free, self-medication and rapid local applications. Diffraction ultraviolet (UV) light lithography offers an advanced method in fabricating poly(ethylene glycol)-based MNs with different shapes, by changing both the UV-light exposure time and photomask design. The exposure time interval is limited at obtaining conical structures with aspect ratio < 1:3, otherwise MNs exhibit reduced fracture load and poor indentation ability, not suitable for practical application. Therefore, this work is focused on a systematic analysis of the MN's base shapes effects on the structural characteristics, skin penetration and drug delivery. Analyzing four different base shapes (circle, triangle, square and star), it has been found that the number of vertices in the polygon base heavily affects these properties. The star-like MNs reveal the most efficient skin penetration ability (equal to 40 % of -their length), due to the edges action on the skin during the perforation. Furthermore, the quantification of the drug delivered by the MNs through ex-vivo porcine skin shows that th
Who reads Effect of Microneedles Shape on Skin Penetration and Transdermal Drug Administration?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Selene De Martino; Mario Battisti; Francesco Napolitano; Antonio Palladino; Luigia Serpico; Eugenio Amendola; Alfonso Martone; Paolo De Girolamo; Antonino Squillace; Principia Dardano; Luca De Stefano; Stefania Dello Iacono
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)