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Can I read Competitive Potentiation of Acetylcholine Effects on Neuronal Nicotinic Receptors by Acetylcholinesterase-Inhibiting Drugs on EtoBox?
Competitive Potentiation of Acetylcholine Effects on Neuronal Nicotinic Receptors by Acetylcholinesterase-Inhibiting Drugs by Ruud Zwart; Regina G. D. M. van Kleef; Cecilia Gotti; Chantal J. G. M. Smulders; Henk P. M. Vijverberg is a Neuroscience article available to read on EtoBox.
What is Competitive Potentiation of Acetylcholine Effects on Neuronal Nicotinic Receptors by Acetylcholinesterase-Inhibiting Drugs about?
**Abstract:** The effects of the acetylcholinesterase inhibitors physostigmine and tacrine on α4β2 and α4β4 subtypes of neuronal nicotinic acetylcholine (ACh) receptors, expressed in __Xenopus laevis__ oocytes, have been investigated. In voltage‐clamp experiments low concentrations of physostigmine and tacrine potentiate ion currents induced by low concentrations of ACh, whereas at high concentrations they inhibit ACh‐induced ion currents. These dual effects result in bell‐shaped concentration—effect curves. Physostigmine and tacrine, by themselves, do not act as nicotinic receptor againsts. The larger potentiation is observed with 10 μ__M__ physostigmine on α4β4 nicotinic receptors and amounts to 70% at 1 μ__M__ ACh. The mechanism underlying the effects of physostigmine on α4β4 ACh receptors has been investigated in detail. Potentiation of ACh‐induced ion current by low concentrations of physostigmine is surmounted at elevated concentrations of ACh, indicating that this is a competitive effect. Conversely, inhibition of ACh‐induced ion current by high concentrations of physostigmine is not surmounted at high concentrations of ACh, and this effect appears mainly due to noncompetiti
Who reads Competitive Potentiation of Acetylcholine Effects on Neuronal Nicotinic Receptors by Acetylcholinesterase-Inhibiting Drugs?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Ruud Zwart; Regina G. D. M. van Kleef; Cecilia Gotti; Chantal J. G. M. Smulders; Henk P. M. Vijverberg
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2008
- Language
- EN
- Field
- Neuroscience (Life Sciences)