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Comparison of a Short Versus Long-course Antibiotic Therapy for Ventilator-associated Pneumonia: a Systematic Review and Meta-analysis of Randomized Controlled Trials by Mohamed Aziz Daghmouri; Emmanuel Dudoignon; Mohamed Ali Chaouch; Josefine Baekgaard; Adrien Bougle; Marc Leone; Benjamin Deniau; François Depret is a Medicine article available to read on EtoBox.
What is Comparison of a Short Versus Long-course Antibiotic Therapy for Ventilator-associated Pneumonia: a Systematic Review and Meta-analysis of Randomized Controlled Trials about?
## Summary ## Background For ventilator-associated pneumonia (VAP), the safety of short-course versus long-course antibiotic therapy is still debated, especially regarding documented VAP due to non-fermenting Gram-negative bacilli (NF-GNB). The aim of this meta-analysis was to assess the rates of recurrence and relapse of VAP in patients receiving short-course (≤8 days) and long-course (≥10–15 days) of antibiotic therapy. ## Methods The protocol for this study was registered in the PROSPERO database (ID: CRD42022365138). We performed an electronic search of the relevant literature and limited our search to data published from 2000 until September 1, 2022. We searched for randomized controlled trials (RCTs) in the United States National Library of Medicine, Cochrane Database of Systematic Reviews (CDSR) and the Cochrane Central Register of Controlled Trials (CENTRAL), Embase, National Institutes of Health PubMed/MEDLINE, web of science and Google Scholar databases. The primary endpoint was the recurrence and relapses of VAP, secondary endpoints were 28-day mortality, mechanical ventilation duration, number of extra-pulmonary infections and length of ICU stay. ## Findings We identifi
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- Author
- Mohamed Aziz Daghmouri; Emmanuel Dudoignon; Mohamed Ali Chaouch; Josefine Baekgaard; Adrien Bougle; Marc Leone; Benjamin Deniau; François Depret
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)