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Galectins as Modulators of Tumor Progression in Head and Neck Squamous Cell Carcinomas by Sven Saussez; Isabelle Camby; Gerard Toubeau; Robert Kiss is a Medicine article available to read on EtoBox.

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## Abstract Head and neck squamous cell carcinomas (HNSCCs) remain a significant cause of morbidity worldwide. Biological therapies able to induce and/or upregulate antitumor immune responses could represent a complementary approach to conventional treatments for patients with HNSCC because, despite advances in surgery, radiotherapy, and chemotherapy, the overall survival rates for these patients have not changed over recent decades. Galectins are involved in the control of cell proliferation, cell death, and cell migration and in the modulation of various functions of the immune system. In this context, galectin‐1 is known to protect HNSCCs from the immune system. The present review details the involvement of galectins in HNSCC biology and suggests a number of approaches to reduce the levels of expression of galectin‐1 in HNSCCs, with the aim of improving the efficiency of HNSCC immunotherapy. © 2007 Wiley Periodicals, Inc. Head Neck, 2007

Who reads Galectins as Modulators of Tumor Progression in Head and Neck Squamous Cell Carcinomas?

Author

Sven Saussez; Isabelle Camby; Gerard Toubeau; Robert Kiss

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)

Published

2007

Language

EN

Field

Medicine (Health Sciences)