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Effect of Maternal Food Restriction on Fetal Rat Lung Lipid Differentiation Program by Ahmet Karadag; Reiko Sakurai; Ying Wang; Pinzheng Guo; Mina Desai; Michael G. Ross; John S. Torday; Virender K. Rehan is a Medicine article available to read on EtoBox.
What is Effect of Maternal Food Restriction on Fetal Rat Lung Lipid Differentiation Program about?
## Abstract Although “fetal programming” has been extensively studied in many organs, there is only limited information on pulmonary effects in the offspring following intrauterine growth restriction (IUGR). We aimed to determine the effects of nutrient restriction on the lung structure and lung lipid differentiation programs in offspring using an animal mode of maternal food restriction (MFR). We utilized a rodent model of 50% MFR from day 10 of gestation to term and then using lung morphology, Western blotting, Real Time RT‐PCR and Oil Red O staining, lung structure and development of the offspring were examined at postnatal days (p) 1, p21, and 9 months (9M). At postnatal day 1, MFR pups weighed significantly less compared to control pups, but at p21 and 9M, they weighed significantly more. However, lung weight, expressed as a percentage of body weight between the two groups was not different at all time‐points examined. The MFR group had significantly decreased alveolar number and significantly increased septal thickness at p1 and 9M, indicating significantly altered lung structure in the MFR offspring. Furthermore, although at p1, compared to the control group, lung lipid accu
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- Author
- Ahmet Karadag; Reiko Sakurai; Ying Wang; Pinzheng Guo; Mina Desai; Michael G. Ross; John S. Torday; Virender K. Rehan
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)