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What is HPV L1 and p16 in Anal SIL Classification about?

This study evaluated the utility of HPV capsid protein L1 and p16 staining in the assessment and classification of anal squamous intraepithelial lesions (SILs). The study found that L1 expression was highest in low-grade SILs and decreased with increasing severity, while p16 expression was diffuse in high-grade SILs. Co-expression of L1 and diffuse p16 was mutually exclusive except in a few focal high-grade lesions within extensive low-grade SILs. The combined evaluation of L1 and p16 staining may help dist

Author

Chemudupati Bharani

Language

EN