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Renal Proteinases and Kidney Hypertrophy in Experimental Diabetes by L. Schaefer; R. M. Schaefer; H. Ling; M. Teschner; A. Heidland is a Medicine article available to read on EtoBox.

What is Renal Proteinases and Kidney Hypertrophy in Experimental Diabetes about?

IDDM is associated with an increase in kidney size, which is due to cellular hypertrophy and progressive matrix accumulation within the glomerulus and throughout the tubulointerstitium. The present study addressed the potential role of cysteine and metalloproteinases in renal hypertrophy of short-term diabetes. Three weeks after induction of streptozotocin diabetes in rats, intraglomerular gelatinase activity (streptozotocin: 23 + 4 vs control: 44 + 3 mU/gg DNA) and cathepsin L + B activity (streptozotocin: 6.7 + 0.8 vs control: 9.3 +\_ 0.7 U/gg DNA) were significantly decreased. Insulin treatment completely prevented the decline in glomerular proteinase activity (gelatinase: 37 + 6 mU/gg DNA; cathepsin L + B: 9.6 + 0.9 U/gg DNA). In isolated proximal tubules a similar pattern of enzyme activity could be observed. Three weeks of diabetes caused a significant decline in cathepsin L + B activity (streptozotocin: 28 + 2 vs control: 37 + 3 U/gg DNA). Insulin treatment again prevented the decline in these tubular proteinase activities. In parallel, kidney weight increased by 22% and glomerular protein/DNA ratio rose by 17 % in untreated diabetic rats. Diabetic rats receiving insulin dis

Who reads Renal Proteinases and Kidney Hypertrophy in Experimental Diabetes?

Author

L. Schaefer; R. M. Schaefer; H. Ling; M. Teschner; A. Heidland

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0012-186X)

Published

1994

Language

EN

Field

Medicine (Health Sciences)