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Platelet Adhesion to Human Umbilical Vein Endothelial Cells Cultured on Anionic Hydrogel Scaffolds by Yong Mei Chen; Masaru Tanaka; Jian Ping Gong; Kazunori Yasuda; Sadaaki Yamamoto; Masatsugu Shimomura; Yoshihito Osada is a Engineering article available to read on EtoBox.
What is Platelet Adhesion to Human Umbilical Vein Endothelial Cells Cultured on Anionic Hydrogel Scaffolds about?
In this work we describe experiments designed to understand the human platelet adhesion to human umbilical vein endothelial cells (HUVECs) cultured on various kinds of chemically cross-linked anionic hydrogels, which were synthesized by radical polymerization. HUVECs could proliferate to sub-confluent or confluent on poly(acrylic acid) (PAA), poly(2-acrylamido-2-methyl-propane sulfonic acid sodium salt) (PNaAMPS), and poly(sodium p-styrene sulfonate) (PNaSS) gels. The proliferation behavior was not sensitive to the crosslinker concentration of the gels. However, the platelet adhesion on the HUVECs cultured on these gels showed different behavior, as revealed by human platelet adhesion test in static conditions. Only a few platelets adhered on the HUVEC sheets cultured on PNaAMPS gels with 4 and 10 mol% cross-linker concentrations, and completely no platelet adhered on the HUVEC sheets cultured on PNaSS gels with 4 and 10 mol% cross-linker concentrations. On the other hand, a large number of platelets adhered on the HUVECs cultured on PAA gels with 1, 2 mol% cross-linker concentrations and PNaAMPS gel with 2 mol% cross-linker concentration. Furthermore, the study showed that promote
Who reads Platelet Adhesion to Human Umbilical Vein Endothelial Cells Cultured on Anionic Hydrogel Scaffolds?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Yong Mei Chen; Masaru Tanaka; Jian Ping Gong; Kazunori Yasuda; Sadaaki Yamamoto; Masatsugu Shimomura; Yoshihito Osada
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2007
- Language
- EN
- Field
- Engineering (Physical Sciences)