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The DEBIT trial: an intervention to reduce antipsychotic polypharmacy prescribing in adult psychiatry wards – a cluster randomized controlled trial by A. Thompson; S. A. Sullivan; M. Barley; S. O. Strange; L. Moore; P. Rogers; A. Sipos; G. Harrison is a Medicine article available to read on EtoBox.
What is The DEBIT trial: an intervention to reduce antipsychotic polypharmacy prescribing in adult psychiatry wards – a cluster randomized controlled trial about?
## Background Clinical guidelines advise against prescribing more than one antipsychotic with limited exceptions. Despite this, surveys continue to report high antipsychotic polypharmacy rates. The aim of the study was to investigate the effectiveness of a multi-faceted intervention in reducing prescribing of antipsychotic polypharmacy on general adult psychiatry wards, compared with guidelines alone. ## Method A pragmatic cluster randomized controlled trial recruited 19 adult psychiatric units (clusters) from the South West of England. Participants were all ward doctors and nurses. The multi-faceted intervention comprised: an educational/CBT workbook; an educational visit to consultants; and a reminder system on medication charts. ## Results The odds of being prescribed antipsychotic polypharmacy in those patients prescribed antipsychotic medication was significantly lower in the intervention than control group when adjusted for confounders (OR 0.43, 95% CI 0.21–0.90, __p__=0.028). There was considerable between-unit variation in polypharmacy rates and in the change in rates between baseline and follow-up (5 months after baseline). ## Conclusion The intervention reduced levels of
Who reads The DEBIT trial: an intervention to reduce antipsychotic polypharmacy prescribing in adult psychiatry wards – a cluster randomized controlled trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- A. Thompson; S. A. Sullivan; M. Barley; S. O. Strange; L. Moore; P. Rogers; A. Sipos; G. Harrison
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Social Sciences)