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Can I read Cardiovascular and Venous Thromboembolic Risk With JAK Inhibitors in Immune-Mediated Inflammatory Skin Diseases: A Systematic Review and Meta-Analysis on EtoBox?
Cardiovascular and Venous Thromboembolic Risk With JAK Inhibitors in Immune-Mediated Inflammatory Skin Diseases: A Systematic Review and Meta-Analysis by Jenne P. Ingrassia; Muhammad Haisum Maqsood; Joel M. Gelfand; Brittany N. Weber; Sripal Bangalore; Kristen I. Lo Sicco; Michael S. Garshick is a Medicine article available to read on EtoBox.
What is Cardiovascular and Venous Thromboembolic Risk With JAK Inhibitors in Immune-Mediated Inflammatory Skin Diseases: A Systematic Review and Meta-Analysis about?
## Importance Janus kinase (JAK) inhibitors are an effective treatment option for patients with certain skin-related conditions, such as atopic dermatitis, alopecia areata, and vitiligo, but there is a current US Food and Drug Administration (FDA) boxed warning label for oral and topical JAK inhibitors regarding increased risk of major adverse cardiovascular events (MACE), venous thromboembolism (VTE), serious infections, malignant neoplasm, and death. However, this boxed warning was precipitated by results of the Oral Rheumatoid Arthritis Trial (ORAL) Surveillance study, which only included patients with rheumatoid arthritis, and the same association may not be observed in dermatologic conditions. ## Objective To determine the risk of all-cause mortality, MACE, and VTE with JAK inhibitors in patients with dermatologic conditions. ## Data Sources PubMed and ClinicalTrials.gov were searched from database inception to April 1, 2023. ## Study Selection This review included phase 3 randomized clinical trials with a placebo/active comparator group of JAK inhibitors used for a dermatologic indication with FDA approval or pending approval or with European Union or Japanese approval. Studi
Who reads Cardiovascular and Venous Thromboembolic Risk With JAK Inhibitors in Immune-Mediated Inflammatory Skin Diseases: A Systematic Review and Meta-Analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jenne P. Ingrassia; Muhammad Haisum Maqsood; Joel M. Gelfand; Brittany N. Weber; Sripal Bangalore; Kristen I. Lo Sicco; Michael S. Garshick
- Publisher
- American Medical Association (AMA)
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)