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Formation of Multinuclear Cells Induced by Dimethyl Sulfoxide: Inhibition of Cytokinesis and Occurrence of Novel Nuclear Division in Dictyostelium Cells by Y Fukui is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Our previous studies showed that 10 percent dimethyl sulfoxide (DMSO) induces the formation of actin microfilament bundles in the cell nucleus together with the dislocation of cortical microfilaments from the plasma membrane. The present study investigated the effects of DMSO on diverse activities mediated by cellular microfilaments as the second step toward assessing potential differences between nuclear and cytoplasmic actins of dictyostelium mucoroides. DMSO was found to reversibly inhibit cell-to- glass as well as cell-to-cell adhesion, cell locomotion, and cell multiplication, whereas cytoplasmic streaming and phagocytosis were not obviously inhibited. Also, 5 percent DMSO inhibited cytokinesis but did not totally inhibit cell growth thus leading to the development of giant cells more than 10 times larger than normal cells. Transmission electron microscopy using serial thin sections showed the occurrence of multinucleation in the DMSO- induced giant cells. After the removal of DMSO, the giant multinuclear cells underwent multiple cytoplasmic cleavage producing normal-sized mononuclear cells. The nuclear division in the DMSO-induced giant cells was unique in that no spindle mic

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Author

Y Fukui

Publisher

The Rockefeller University Press

Published

1980

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)