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BCL‐2 and BAX proteins expression throughout the light–dark cycle and modifications induced by sleep deprivation and rebound in adult rat brain by Corinne J. Montes‐Rodríguez; Silvestre Alavez; Edgar Soria‐Gómez; Pavel E. Rueda‐Orozco; Khalil Guzman; Julio Morán; Oscar Prospéro‐García is a Neuroscience article available to read on EtoBox.
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## Abstract It has been suggested that sleep has a restorative function; however, experimental support is limited. Hence, we investigated whether changes in the level of antiapoptotic BCL‐2 protein and proapoptotic BAX protein occur during sleep deprivation (SD) and sleep rebound, and evaluated the spontaneous changes in these proteins, along the light–dark cycle, in the adult male Wistar rat. Estimations were made in the prefrontal cortex, hippocampus, striatum, and pons. We observed that BCL‐2 exhibited diurnal variations in the prefrontal cortex and striatum, whereas BAX varied in the striatum and showed only small variations in the pons as measured by immunoblotting. The BCL‐2/BAX ratio exhibited diurnal variations in the prefrontal cortex and striatum. BCL‐2 and BAX levels were affected by 24 hr of total SD and 24 hr of sleep rebound. SD decreased the BCL‐2/BAX ratio in the prefrontal cortex and pons. Sleep rebound increased the BCL‐2/BAX ratio in the hippocampus. In conclusion, the BCL‐2/BAX ratio is high during the dark phase as compared with the light phase in the prefrontal cortex and during the light phase as compared with the dark phase in the striatum. SD decreased the
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- Author
- Corinne J. Montes‐Rodríguez; Silvestre Alavez; Edgar Soria‐Gómez; Pavel E. Rueda‐Orozco; Khalil Guzman; Julio Morán; Oscar Prospéro‐García
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2009
- Language
- EN
- Field
- Neuroscience (Life Sciences)