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Dynamic imaging with lanthanide chelates in normal brain: Contrast due to magnetic susceptibility effects by Arno Villringer; Bruce R. Rosen; John W. Belliveau; Jerome L. Ackerman; Randall B. Lauffer; Richard B. Buxton; Yong-Sheng Chao; Van J. Wedeenand; Thomas J. Brady is a Medicine article available to read on EtoBox.
What is Dynamic imaging with lanthanide chelates in normal brain: Contrast due to magnetic susceptibility effects about?
Using a onedimensional rapid imaging technique, we have found that injection of lanthanide chelates such as Gd(DTPA)'-leads to a significant decrease (50%) in rat brain signal intensity at 1.45 T using T,-weighted pulse sequences; however, no effect of comparable size is observed with TI-weighted pulse sequences. The transient effect and its kinetics were followed with a temporal resolution of between 1 and 8 s. Experiments with different lanthanide chelates show that the observed decrease in signal intensity correlates with the magnetic moment of each agent but not with their longitudinal relaxivity. Threedimensional chemical-shift resolved experiments demonstrate significant line broadening in brain during infusion with Dy(DTPA)'-. Our results show that the cause of this effect is the difference in susceptibility between the capillaries, containing the contrast agent, and the surrounding tissue. As a result of these susceptibility differences, field gradients are produced in the tissue and diffusion of water through these gradients leads to a loss of spin phase coherence and thus a decrease in signal intensity. We propose this as a new type of contrast agent mechanism in NMR. The
Who reads Dynamic imaging with lanthanide chelates in normal brain: Contrast due to magnetic susceptibility effects?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Arno Villringer; Bruce R. Rosen; John W. Belliveau; Jerome L. Ackerman; Randall B. Lauffer; Richard B. Buxton; Yong-Sheng Chao; Van J. Wedeenand; Thomas J. Brady
- Published
- 1988
- Language
- EN
- Field
- Medicine (Health Sciences)