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Hsp 27 Is Better Associated with the Expression of Inducible Thermotolerance in Human Pancreatic Tumor Cell Lines Than Hsp 70, P53 or P21/waf1/cip1 by Cheng E. Ng; S. Qutob; M. Pavliv; P. Lamarche; J.P. Mao; G. Peter Raaphorst is a Environmental Science article available to read on EtoBox.

What is Hsp 27 Is Better Associated with the Expression of Inducible Thermotolerance in Human Pancreatic Tumor Cell Lines Than Hsp 70, P53 or P21/waf1/cip1 about?

We evaluated the levels of p53, p21/waf1/cip1, hsp 27 and hsp 70 proteins in confluent cultures of human pancreatic tumor cell lines during the expression of inducible thermotolerance (IT). Two of these cell lines have wild type, whereas the other two have mutant, p53 status. Three cell lines expressed a significant amount of IT (p50.05 and better, onetailed Student's t-test); the fourth manifested little IT. Hsp 70 was upregulated in all cell lines. In contrast, hsp 27 was upregulated only in the cell lines that expressed IT. There was no correlation between either p53, or p21, protein levels and propensity to express IT. We conclude that hsp 27 is better associated with the expression of IT than hsp 70 in these cell lines.

Who reads Hsp 27 Is Better Associated with the Expression of Inducible Thermotolerance in Human Pancreatic Tumor Cell Lines Than Hsp 70, P53 or P21/waf1/cip1?

Author

Cheng E. Ng; S. Qutob; M. Pavliv; P. Lamarche; J.P. Mao; G. Peter Raaphorst

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0306-4565)

Published

2002

Language

EN

Field

Environmental Science (Life Sciences)