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Can I read Synthesis of Bicyclic γ-Lactams via Oxazolidinones on EtoBox?
Synthesis of Bicyclic γ-Lactams via Oxazolidinones by Jack E. Baldwin; E. Lee is a Chemistry article available to read on EtoBox.
What is Synthesis of Bicyclic γ-Lactams via Oxazolidinones about?
Oxazolidlnone aldehyde 2 reacts with L-cysteine methyl ester to produoe N-hydroxymethyl bicyclic Y-lactam 11 in a double cyclisation reaction. With ;-cyateine methyl eater, an eplmeric mixture of N-hydroxymethyl bicyclic Y-lactama 12 is obtained. Bicyclic Y-lactama 3, f! and 12 are easily prepared from 11 and 12. We recently communicated the synthesis of a Y-lactam analogue 1 of the penema which showed weak but real antibacterial activities.' N-Benzyloxyoarbonyl-L\_aspart.ic semi-aldehyde benzyl eater (2) was reacted with cyatelne methyl eaters to obtain the bicyclic Y-lactama 1 (2!, 55. 72; from &-cyateine methyl eater) and '( (22, 5!, '72; from g-cystelne methyl ester) in refluxing pyridlne.
Who reads Synthesis of Bicyclic γ-Lactams via Oxazolidinones?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Jack E. Baldwin; E. Lee
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)
- Published
- 1986
- Language
- EN
- Field
- Chemistry (Physical Sciences)