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Development of Selective DNA-Interacting Ligands : Understanding the Function of Non-canonical DNA Structures by Sefan Asamitsu is a nonfiction available to read on EtoBox.

What is Development of Selective DNA-Interacting Ligands : Understanding the Function of Non-canonical DNA Structures about?

This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases.   Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity.    This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to

Who reads Development of Selective DNA-Interacting Ligands : Understanding the Function of Non-canonical DNA Structures?

Author

Sefan Asamitsu

Publisher

Springer Singapore, Imprint Springer

Published

2020

Language

EN

ISBN

9789811577154

Category

nonfiction

Subjects

Science, Chemistry, Medical