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MOG antibody prevalence in adult optic neuritis and clinical predictive factors for diagnosis: A Chinese cohort study by Honglu Song; Mo Yang; Huanfen Zhou; Zhaohui Li; Shihui Wei is a Medicine article available to read on EtoBox.

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Objective Because AQP4/MOG antibody testing is not available in some parts of the world and there are often delays in obtaining results, it is particularly important to use clinical factors to predict the subtypes of adult optic neuritis (ON). Methods This was a single-center retrospective cohort study. Results The final analysis included 249 adult patients presenting with the first ON attack during January 2016 to January 2020. These included 109 (43.8%) AQP4-ON cases, 49 (19.7%) MOG-ON cases, and 91 (36.5%) Seronegative-ON cases. The proportion of optic disk swelling (ODS) and bilateral involvement in MOG-ON group was significantly higher than in the other two subgroups (P = 0.029, 0.001). The MOG-ON group had the best follow-up BCVA (P = 0.003). To predict adult AQP4-ON, unilateral involvement (sensitivity 0.88, NPV 0.77) was the most sensitivity predictors, while neurological history (specificity 0.96, PPV 0.65) and concomitant other autoimmune antibodies (specificity 0.76, PPV 0.65) were the most specific predictors. Using the parallel test ‘unilateral or other autoimmune antibodies’ increased sensitivity to 0.95, with an optimal NPV of 0.88. To predict adult MOG-ON, the most

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Author

Honglu Song; Mo Yang; Huanfen Zhou; Zhaohui Li; Shihui Wei

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)