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Chromatin replication by Claudia Gruss; Josém. Sogo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Chromatin replication about?

Just as the faithful replication of DNA is an essential process for the cell, chromatin structures of active and inactive genes have to be copied accurately. Under certain circumstances, however, the activity pattern has to be changed in specific ways. Although analysis of specific aspects of these complex processes, by means of model systems, has led to their further elucidation, the mechanisms of chromatin replication in vivo are still controversial and far from being understood completely. Progress has been achieved in understanding: 1. The initiation of chromatin replication, indicating that a nucleosome-free origin is necessary for the initiation of replication; 2. The segregation of the parental nucleosomes, where convincing data support the model of random distribution of the parental nucleosomes to the daughter strands; and 3. The assembly of histones on the newly synthesized strands, where growing evidence is emerging for a two-step mechanism of nucleosome assembly, starting with the deposition of H3/H4 tetramers onto the DNA, followed by H2A/H2B dimers. ## Chromatin Replication Every time a cell divides, not only is the DNA itself replicated, but the newly synthesized str

Who reads Chromatin replication?

Author

Claudia Gruss; Josém. Sogo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0265-9247)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)