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Can I read Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats on EtoBox?
Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats by Asad Ur Rahman; Fiaz Alam; Muhammad Khan; Muhammad Sarfraz; Abdul Basit; Tawseef Ahmad; Muhammad Ali Khokhar; Sayyad Ali; Kifayat Ullah Khan is a Chemistry article available to read on EtoBox.
What is Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats about?
The traditional use of __Mirabilis jalapa__ L. roots to enhance male sexual performance prompted us to assess the in silico, in vitro, and in vivo aphrodisiac activities of its hydroethanolic extract using normal male rats. Spectroscopic characterization indicated the presence of ß-D-glucopyranoside, methyl-1,9-benzyl-2,6-dichloro-9H-purine, and Bis-(2-ethylhexyl)-phthalate; these compounds have a significant inhibitory effect on the phosphodiesterase-5 (PDE-5) enzyme in silico evaluation and minerals (including zinc, cadmium, and magnesium). Other phytochemical analyses revealed the presence of phenolic compounds and flavonoids. These phytochemicals and minerals may contribute to the aphrodisiac activities of the extract. Additionally, the in vivo study revealed that the administration of __M. jalapa__ root extract (300 mg/kg) significantly enhanced (__p__ < 0.01, __p__ < 0.03) mount, intromission, and ejaculation frequencies while significantly (__p__ < 0.05) decreasing the mount and intromission latencies, as well as the post-ejaculatory interval time, in comparison with the standard drugs sildenafil and ginseng, resulting in enhanced erection and sexual performance in the rats.
Who reads Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats?
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- Author
- Asad Ur Rahman; Fiaz Alam; Muhammad Khan; Muhammad Sarfraz; Abdul Basit; Tawseef Ahmad; Muhammad Ali Khokhar; Sayyad Ali; Kifayat Ullah Khan
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Life Sciences)