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Ablation for Atrial Fibrillation Improves the Outcomes in Patients with Heart Failure with Preserved Ejection Fraction by Zhonglei Xie; Baozhen Qi; Zimu Wang; Fuhai Li; Chaofeng Chen; Chaofu Li; Shuai Yuan; Shun Yao; Jingmin Zhou; Junbo Ge is a Medicine article available to read on EtoBox.

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## Abstract ## Aims Patients with heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) have worse clinical outcomes than those with sinus rhythm (SR). We aim to investigate whether maintaining SR in patients with HFpEF through a strategy such as AF ablation would improve outcomes. ## Methods and results This is a cohort study that analysed 1034 patients (median age 69 [63–76] years, 46.2% [478/1034] female) with HFpEF and AF. Of these, 392 patients who underwent first-time AF ablation were assigned to the ablation group, and the remaining 642 patients, who received only medical therapy, were assigned to the no ablation group. The primary endpoint was a composite of all-cause death or rehospitalization for worsening heart failure. After a median follow-up of 39 months, the cumulative incidence of the primary endpoint was significantly lower in the ablation group compared to the no ablation group (adjusted hazard ratio [HR], 0.55 [95% CI, 0.37–0.82], __P__ = 0.003) in the propensity score-matched model. Secondary endpoint analysis showed that the benefit of AF ablation was mainly driven by a reduction in rehospitalization for worsening heart failure (ad

Who reads Ablation for Atrial Fibrillation Improves the Outcomes in Patients with Heart Failure with Preserved Ejection Fraction?

Author

Zhonglei Xie; Baozhen Qi; Zimu Wang; Fuhai Li; Chaofeng Chen; Chaofu Li; Shuai Yuan; Shun Yao; Jingmin Zhou; Junbo Ge

Publisher

Oxford University Press

Published

2023

Language

EN

Field

Medicine (Health Sciences)