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Can I read Superoxide protects Escherichia coli from bleomycin mediated lethality on EtoBox?
Superoxide protects Escherichia coli from bleomycin mediated lethality by Richard M. Burger; Karl Drlica is a Chemistry article available to read on EtoBox.
What is Superoxide protects Escherichia coli from bleomycin mediated lethality about?
Superoxide and its products, especially hydroxyl radical, were recently proposed to be instrumental in cell death following treatment with a wide range of antimicrobials. Surprisingly, bleomycin lethality to Escherichia coli was ameliorated by a genetic deficiency of superoxide dismutase or by furnishing the superoxide generator plumbagin. Rescue by plumbagin was similar in strains containing or lacking recA or with inactive, inducible, or constitutive soxRS regulons. Thus, superoxide interferes with bleomycin cytotoxicity in ways not readily explained by genetic pathways expected to protect from oxidative damage.
Who reads Superoxide protects Escherichia coli from bleomycin mediated lethality?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Richard M. Burger; Karl Drlica
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)
- Published
- 2009
- Language
- EN
- Field
- Chemistry (Physical Sciences)