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Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation* by Burckart, Gilbert J.; Frye, Reginald F.; Kelly, Patrick; Branch, Robert A.; Jain, Ashok; Fung, John J.; Starzl, Thomas E.; Venkataramanan, Raman is a Medicine article available to read on EtoBox.

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## Objective: To examine the phenotypic expression of cyp2e1 in liver transplant patients, as measured by the in vivo probe chlorzoxazone, and to evaluate cyp2e1 activity over time after transplantation. ## Methods: Thirty-three stable liver transplant patients were given 250 mg chlorzoxazone within 1 year after transplantation as part of a multiprobe cyp cocktail; urine and blood were collected for 8 hours. chlorzoxazone and 6-hydroxychlorzoxazone concentrations were determined by hplc. twenty-eight healthy control subjects, eight patients with moderate to severe liver disease, and four patients who had not received liver transplants were also studied for comparison. the chlorzoxazone metabolic ratio, calculated as the plasma concentration of 6-hydroxychlorzoxazone/chlorzoxazone at 4 hours after chlorzoxazone administration, was used as the phenotypic index. in a subgroup of patients and control subjects, additional blood samples were obtained to allow for the calculation of chlorzoxazone pharmacokinetic parameters by noncompartmental methods. ## Results: The chlorzoxazone metabolic ratio for the liver transplant patients in the first month after transplantation (mean +/- sd, 6.4

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Author

Burckart, Gilbert J.; Frye, Reginald F.; Kelly, Patrick; Branch, Robert A.; Jain, Ashok; Fung, John J.; Starzl, Thomas E.; Venkataramanan, Raman

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

1998

Language

EN

Field

Medicine (Health Sciences)