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P2Y12 Inhibitor Monotherapy Combined With Colchicine Following PCI in ACS Patients by Seung-Yul Lee; Young-Hoon Jeong; Kyeong Ho Yun; Jae Young Cho; Diana A. Gorog; Dominick J. Angiolillo; Jin Won Kim; Yangsoo Jang is a Medicine article available to read on EtoBox.

What is P2Y12 Inhibitor Monotherapy Combined With Colchicine Following PCI in ACS Patients about?

BACKGROUND After a brief period of dual antiplatelet therapy, P2Y 12 inhibitor monotherapy in the absence of aspirin effectively reduces bleeding without increasing recurrent ischemia in patients undergoing percutaneous coronary intervention (PCI). In addition, early anti-inflammatory therapies may have clinical benefits in acute coronary syndrome (ACS) patients. OBJECTIVES The aim of this study was to investigate the feasibility of ticagrelor or prasugrel P2Y 12 inhibitor monotherapy combined with colchicine immediately after PCI in patients with ACS. METHODS This was a proof-of-concept pilot trial. ACS patients treated with drug-eluting stents were included. On the day after PCI, low-dose colchicine (0.6 mg daily) was administered in addition to ticagrelor or prasugrel maintenance therapy, whereas aspirin therapy was discontinued. The primary outcome was any stent thrombosis at 3 months. The key secondary outcomes were platelet reactivity measured by the VerifyNow assay (Accriva) before discharge and a reduction in high-sensitivity C-reactive protein (hs-CRP) over 1 month. ## Results We enrolled 200 patients, 190 (95.0%) of whom completed the 3-month follow-up. The primary outcom

Who reads P2Y12 Inhibitor Monotherapy Combined With Colchicine Following PCI in ACS Patients?

Author

Seung-Yul Lee; Young-Hoon Jeong; Kyeong Ho Yun; Jae Young Cho; Diana A. Gorog; Dominick J. Angiolillo; Jin Won Kim; Yangsoo Jang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)