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Increased Cell Proliferation Activity and Decreased Cell Death Are Associated with the Emergence of Hormone-refractory Recurrent Prostate Cancer by Koivisto, Pasi; Visakorpi, Tapio; Rantala, Immo; Isola, Jorma is a Medicine article available to read on EtoBox.

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The tumour growth kinetics (cell proliferation and apoptosis) of ten hormone-refractory locally recurrent prostate cancers were compared with their matched untreated primary tumour specimens. All recurrent tumours had a higher cell proliferation activity, as defined by Ki-67 immunohistochemistry, than corresponding primary tumours from the same patients. The mean cell proliferation activity in recurrences (13•5 3•8 per cent) was over two times higher (P<0•0001) than that in primary tumours (5•5 2•4 per cent), suggesting that cell clones which progress during androgen withdrawal are actively stimulated to proliferate. The mean percentage of apoptotic cells, as estimated by the in situ end-labelling technique, was 5•4 4•7 per cent in untreated primary tumours, whereas it was 2•3 1•5 per cent in locally recurrent tumours (P=0•05). In all but two cases, the apoptotic index was lower in recurrent than in corresponding primary tumours, suggesting that recurrent prostate carcinomas are able to avoid apoptosis in the androgen-deprived environment. In conclusion, the clinical progression of prostate cancer during androgen withdrawal is associated with increased cell proliferation and decrea

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Author

Koivisto, Pasi; Visakorpi, Tapio; Rantala, Immo; Isola, Jorma

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1997

Language

EN

Field

Medicine (Health Sciences)