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Can I read Cyclotron produced ^132^La as a PET imaging surrogate of therapeutic ^225^Ac on EtoBox?
Cyclotron produced ^132^La as a PET imaging surrogate of therapeutic ^225^Ac by Eduardo Aluicio-Sarduy; Todd E. Barnhart; Jamey Weichert; Reinier Hernandez; Jonathan W. Engle is a Medicine article available to read on EtoBox.
What is Cyclotron produced ^132^La as a PET imaging surrogate of therapeutic ^225^Ac about?
The aim of this work is to explore 132 La as a PET imaging surrogate of 225 Ac using a DOTA-based, tumor-targeting alkylphosphocholine (NM600). Methods: 132 La was produced on a biomedical cyclotron. For in vivo experiments, mice bearing 4T1 tumors were administered 132 La-NM600, and PET/CT scans were acquired up to 24h post-injection (p.i.). Following the last timepoint, ex vivo tissue distribution was measured to corroborate in vivo PET data. Ex vivo tissue distribution was performed at 4h and 24h p.i. in mice injected with 225 Ac-NM600. Results: PET/CT images showed elevated, persistent 132 La-NM600 uptake in the tumor. Low bone accumulation confirmed the in vivo stability of the conjugate. Ex vivo biodistribution validated the image-derived quantitative data, and the comparison of the 132 La-NM600 and 225 Ac-NM600 tissue distribution
Who reads Cyclotron produced ^132^La as a PET imaging surrogate of therapeutic ^225^Ac?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Eduardo Aluicio-Sarduy; Todd E. Barnhart; Jamey Weichert; Reinier Hernandez; Jonathan W. Engle
- Publisher
- The Society of Nuclear Medicine; Society of Nuclear Medicine; Society of Nuclear Medicine, Inc. (ISSN 0161-5505)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)