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Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure: Decision analytic modelling using data from a feasibility trial by Praveen Thokala; Gordon W Fuller; Steve Goodacre; Samuel Keating; Esther Herbert; Gavin Perkins; Andy Rosser; Imogen Gunson; Joshua Miller; Matthew Ward; Mike Bradburn; Tim Harris; Maggie Marsh; Kate Ren; Cindy Cooper is a scholarly article available to read on EtoBox.

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## Abstract Background Standard prehospital management for Acute respiratory failure (ARF) involves controlled oxygen therapy. Continuous positive airway pressure (CPAP) is a potentially beneficial alternative treatment, however, it is uncertain whether this could improve outcomes and provide value for money. This study aimed to evaluate the cost-effectiveness of prehospital CPAP in ARF.Methods A cost-utility economic evaluation was performed using a probabilistic decision tree model synthesising available evidence. The model consisted of a hypothetical cohort of patients in a representative ambulance service with undifferentiated ARF, receiving standard oxygen therapy or prehospital CPAP. Costs and quality adjusted life years (QALYs) were estimated using methods recommended by NICE.Results In the base case analysis, using CPAP effectiveness estimates form the ACUTE trial, the mean expected costs of standard care and prehospital CPAP were £15,201 and £14,850 respectively and the corresponding mean expected QALYs were 1.190 and 1.128, respectively. The mean ICER estimated as standard oxygen therapy compared to prehospital CPAP was £5,685 per QALY which indicated that standard oxygen

Author

Praveen Thokala; Gordon W Fuller; Steve Goodacre; Samuel Keating; Esther Herbert; Gavin Perkins; Andy Rosser; Imogen Gunson; Joshua Miller; Matthew Ward; Mike Bradburn; Tim Harris; Maggie Marsh; Kate Ren; Cindy Cooper

Publisher

Research Square Platform LLC

Published

2021

Language

EN