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Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation by Stacy Robertson; Gonzalo J. Martínez; Cloe A. Payet; Jennifer Y. Barraclough; David S. Celermajer; Christina Bursill; Sanjay Patel is a Medicine article available to read on EtoBox.
What is Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation about?
Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis-associated inflammation. This study aims to assess in acute coronary syndrome (ACS) patients (1) inflammasome activation in circulating monocytes and (2) whether short-term oral colchicine, a recognized anti-inflammatory agent that has been shown to be cardio-protective in clinical studies, might acutely suppress inflammasome-dependent inflammation. ACS patients (n=21) were randomized to oral colchicine (1 mg followed by 0.5 mg 1 h later) or no treatment, and compared with untreated healthy controls (n=9). Peripheral venous blood was sampled pre- (day 1) and 24 h post- (day 2) treatment. Monocytes were cultured and stimulated with ATP. Analysis of key inflammasome markers was performed by ELISA. IL-1β secretion increased by 580.4% (P<0.01) in ACS patients compared with controls but only with ATP stimulation. Untreated ACS patients secreted significantly higher levels of IL-18 compared with healthy controls independent of ATP stimulation (P<0.05). Colchicine treatment in ACS patients markedly reduced intracellular and secret
Who reads Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Stacy Robertson; Gonzalo J. Martínez; Cloe A. Payet; Jennifer Y. Barraclough; David S. Celermajer; Christina Bursill; Sanjay Patel
- Publisher
- Portland Press Ltd.
- Published
- 2016
- Language
- EN
- Field
- Medicine (Health Sciences)