Opening book details…
Can I read Brain histamine H~1~ receptor occupancy after oral administration of desloratadine and loratadine on EtoBox?
Brain histamine H~1~ receptor occupancy after oral administration of desloratadine and loratadine by Tadaho Nakamura; Kotaro Hiraoka; Ryuichi Harada; Takuro Matsuzawa; Yoichi Ishikawa; Yoshihito Funaki; Takeo Yoshikawa; Manabu Tashiro; Kazuhiko Yanai; Nobuyuki Okamura is a Medicine article available to read on EtoBox.
What is Brain histamine H~1~ receptor occupancy after oral administration of desloratadine and loratadine about?
## Abstract Some histamine H~1~ receptor (H~1~R) antagonists induce adverse sedative reactions caused by blockade of histamine transmission in the brain. Desloratadine is a second‐generation antihistamine for treatment of allergic disorders. Its binding to brain H~1~Rs, which is the basis of sedative property of antihistamines, has not been examined previously in the human brain by positron emission tomography (PET). We examined brain H~1~R binding potential ratio (BPR), H~1~R occupancy (H~1~RO), and subjective sleepiness after oral desloratadine administration in comparison to loratadine. Eight healthy male volunteers underwent PET imaging with [^11^C]‐doxepin, a PET tracer for H~1~Rs, after a single oral administration of desloratadine (5 mg), loratadine (10 mg), or placebo in a double‐blind crossover study. BPR and H~1~RO in the cerebral cortex were calculated, and plasma concentrations of loratadine and desloratadine were measured. Subjective sleepiness was quantified by the Line Analogue Rating Scale (LARS) and the Stanford Sleepiness Scale (SSS). BPR was significantly lower after loratadine administration than after placebo (0.504 ± 0.074 vs 0.584 ± 0.059 [mean ± SD], __P__<0
Who reads Brain histamine H~1~ receptor occupancy after oral administration of desloratadine and loratadine?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tadaho Nakamura; Kotaro Hiraoka; Ryuichi Harada; Takuro Matsuzawa; Yoichi Ishikawa; Yoshihito Funaki; Takeo Yoshikawa; Manabu Tashiro; Kazuhiko Yanai; Nobuyuki Okamura
- Publisher
- Wiley
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)