About this document

AGN194204: RXR-Selective Retinoid in Pancreatic Cancer by Khalid Yahya is a document available to read on EtoBox.

1) The study examines the effects of AGN194204, a novel and highly selective RXR-retinoid, on suppressing the proliferation of human pancreatic cancer cells. 2) Results showed that AGN194204 inhibited proliferation in two pancreatic cancer cell lines (MIA PaCa-2 and BxPC-3) at concentrations above 10 nM, but not in the AsPC-1 cell line. AGN194204 was 10-100 times more effective at inhibiting proliferation than RAR-selective retinoids. 3) The inhibition was mediated through RXR, as it was reversed by an

Author

Khalid Yahya

Language

EN