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Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas by Efthimios Sivridis; Alexandra Giatromanolaki; Panagiotis Anastasiadis; Loukas Georgiou; Kevin C. Gatter; Adrian L. Harris; Roy Bicknell; Michael I. Koukourakis is a Medicine article available to read on EtoBox.

What is Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas about?

## Abstract Vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP) are important angiogenic enzymes, inducing new blood vessel formation in many human malignancies. In this study, the immunohistochemical expression of the two molecules was analysed in a series of 121 endometrial carcinomas. VEGF was expressed exclusively in cancer cells, while TP expression was shown in cancer cells (TPcc) and in stromal cells (TPsc) of both fibroblastic and myometrial origin. In all cases, enzymatic detection was particularly evident at the invading tumour front. At this site, TPsc, but not VEGF, expression was associated with non‐endometrioid‐type carcinomas, high tumour grade, deep myometrial invasion, and advanced stage. VEGF, but not TP, expression was related to increased angiogenesis (__p__=0.01). Double stratification of the two factors, however, marked VEGF/TPsc co‐expression as the most potent angiogenic phenotype (__p__=0.008), suggesting a synergistic function. Survival analysis revealed that VEGF and TPsc, whether expressed alone or in combination, define poor prognosis. In multivariate analysis, however, stage of disease (__p__<0.0001, __t__‐ratio 4.4) and VEGF exp

Who reads Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas?

Author

Efthimios Sivridis; Alexandra Giatromanolaki; Panagiotis Anastasiadis; Loukas Georgiou; Kevin C. Gatter; Adrian L. Harris; Roy Bicknell; Michael I. Koukourakis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2002

Language

EN

Field

Medicine (Health Sciences)