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Bronchiolitis Phenotypes Identified by Latent Class Analysis May Influence the Occurrence of Respiratory Sequelae by Laura Petrarca; Raffaella Nenna; Greta Di Mattia; Antonella Frassanito; Jose A. Castro‐Rodriguez; Carlos E. Rodriguez Martinez; Enrica Mancino; Serena Arima; Carolina Scagnolari; Alessandra Pierangeli; Fabio Midulla is a Medicine article available to read on EtoBox.
What is Bronchiolitis Phenotypes Identified by Latent Class Analysis May Influence the Occurrence of Respiratory Sequelae about?
## Abstract ## Background The heterogeneity of bronchiolitis may imply or reflect a different predisposition to respiratory sequelae. ## Objective Our aim was to investigate whether, among infants hospitalized with bronchiolitis, different clinical profiles extracted by latent class analysis (LCA) are associated with different risks of wheezing. ## Methods Over 15 consecutive epidemic seasons (2004–2019), we prospectively enrolled infants <1 year hospitalized for the first episode of bronchiolitis in a single tertiary hospital. A detailed clinical questionnaire was filled for each infant. LCA was applied to differentiate bronchiolitis phenotypes, and after hospital discharge, a phone interview was performed annually to record the presence of wheezing episodes. Adjusted multivariate regression analyses were run to investigate the risk of wheezing during 7 years follow‐up according to clinical phenotypes. ## Results LCA performed on 1312 infants resulted in a three‐class model. Profile 1 (65.5%): moderate bronchiolitis; Profile 2 (6.1%): severe bronchiolitis; and Profile 3(28.4%): bronchiolitis infants with high eosinophils blood count. At 1 year of follow up, about 50% of children p
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- Author
- Laura Petrarca; Raffaella Nenna; Greta Di Mattia; Antonella Frassanito; Jose A. Castro‐Rodriguez; Carlos E. Rodriguez Martinez; Enrica Mancino; Serena Arima; Carolina Scagnolari; Alessandra Pierangeli; Fabio Midulla
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)