Can I read Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection on EtoBox?
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection by Xintong Dong; Nathachit Limjunyawong; Elizabeth I. Sypek; Gaofeng Wang; Roger V. Ortines; Christine Youn; Martin P. Alphonse; Dustin Dikeman; Yu Wang; Mark Lay; Ruchita Kothari; Chirag Vasavda; Priyanka Pundir; Loyal Goff; Lloyd S. Miller; Wuyuan Lu; Luis A. Garza; Brian S. Kim; Nathan K. Archer; Xinzhong Dong is a Immunology and Microbiology article available to read on EtoBox.
What is Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection about?
Healthy skin maintains a diverse microbiome and a potent immune system to fight off infections. Here, we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled receptors (GPCRs) Mrgpra2a/b on neutrophils. This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis. We generated mutant mouse lines lacking the entire Defensin (Def) gene cluster in keratinocytes or Mrgpra2a/b. Def and Mrgpra2 mutant animals both exhibited skin dysbiosis, with reduced microbial diversity and expansion of Staphylococcus species. Defensins and Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil abscesses, a hallmark of antibacterial immunity. Activation of Mrgpra2 by defensin triggered neutrophil release of IL-1β and CXCL2 which are vital for proper amplification and propagation of the antibacterial immune response. This study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis in maintaining healthy skin ecology and promoting antibacterial host defense.
Who reads Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Xintong Dong; Nathachit Limjunyawong; Elizabeth I. Sypek; Gaofeng Wang; Roger V. Ortines; Christine Youn; Martin P. Alphonse; Dustin Dikeman; Yu Wang; Mark Lay; Ruchita Kothari; Chirag Vasavda; Priyanka Pundir; Loyal Goff; Lloyd S. Miller; Wuyuan Lu; Luis A. Garza; Brian S. Kim; Nathan K. Archer; Xinzhong Dong
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)