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Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells by Janina Ratajczak; Marcin Majka; Jacek Kijowski; Monika Baj; Zhixing K. Pan; Leah A. Marquez; Anna Janowska-Wieczorek; Mariusz Z. Ratajczak is a Medicine article available to read on EtoBox.
What is Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells about?
The aim of this study was to identify signal transduction pathways activated by erythropoietin (EpO) and erythropoietin co‐stimulatory factors (kit ligand), insulin‐like growth factor, thrombopoietin, interleukin 3 and granulocyte‐macrophage colony‐stimulating factor) in normal human bone marrow CD34^+^ cells and d 11 erythroid burst forming unit derived glycophorin^+^ cells. The activation of these signal transduction pathways was further correlated with various biological effects such as (i) cell proliferation, (ii) inhibition of apoptosis, (iii) activation of adhesion and (iv) secretion of the matrix metalloproteinases (MMPs) MMP‐9 and MMP‐2, and vascular endothelial growth factor (VEGF). We found that in human CD34^+^ cells and erythroblasts erythropoietic factors may activate similar but different signalling pathways, and that activation of each of the JAK‐STAT, MAPK p42/44 or PI‐3K‐AKT axes alone is not sufficient either to stimulate cell proliferation or inhibit apoptosis, suggesting that these processes are regulated by orchestrated activation of multiple signalling cascades. Accordingly, we found that although cell proliferation was more related to simultaneous activation
Who reads Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells?
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- Author
- Janina Ratajczak; Marcin Majka; Jacek Kijowski; Monika Baj; Zhixing K. Pan; Leah A. Marquez; Anna Janowska-Wieczorek; Mariusz Z. Ratajczak
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)