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Oligoclonal Bands in the Cerebrospinal Fluid and Increased Brain Atrophy in Early Stages of Relapsing-remitting Multiple Sclerosis by Juan Ignacio Rojas; Liliana Patrucco; Santiago Tizio; Edgardo Cristiano is a Medicine article available to read on EtoBox.

What is Oligoclonal Bands in the Cerebrospinal Fluid and Increased Brain Atrophy in Early Stages of Relapsing-remitting Multiple Sclerosis about?

## Objective: To determine if the presence of oligoclonal bands (ob) at early stages of multiple sclerosis was associated with higher brain atrophy, when compared with patients without ob. ## Methods: Relapsing-remitting multiple sclerosis (rrms) patients with less than two years of disease onset and ob detection in cerebrospinal fluid (csf) were included. sienax was used for total brain volume (tbv), gray matter volume (gmv), and white matter volume (wmv). ## Results: Forty patients were included, 29 had positive igg-ob. no differences were found between positive and negative patients in gender, expanded disability status scale (edss), treatment received, and t2/t1 lesion load. tbv in positive igg-ob patients was 1.5 mm3 x 10(6) compared with 1.64 mm3 x 10(6) in the negative ones (p=0.02). gmv was 0.51 mm3 x 10(6) in positive igg-ob compared with 0.62 mm3 x 10(6) in negative ones (p=0.002). no differences in wmv (p=0.09) were seen. ## Conclusions: Igg-ob in the csf was related to neurodegeneration magnetic resonance (mr) markers in early rrms.

Who reads Oligoclonal Bands in the Cerebrospinal Fluid and Increased Brain Atrophy in Early Stages of Relapsing-remitting Multiple Sclerosis?

Author

Juan Ignacio Rojas; Liliana Patrucco; Santiago Tizio; Edgardo Cristiano

Publisher

SciELO; Associacao Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange; São Paulo SP: Academia Brasileira de Neurologia; FapUNIFESP (SciELO) (ISSN 0004-282X)

Published

2012

Language

EN

Field

Medicine (Health Sciences)