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A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat by Peer B. Jacobson; Sheryl J. Morgan; Denise M. Wilcox; Phong Nguyen; Christine A. Ratajczak; Richard P. Carlson; Richard R. Harris; Merrill Nuss is a Medicine article available to read on EtoBox.

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Objective. To noninvasively examine the pathogenesis of rat adjuvant-induced arthritis (AIA) by magnetic resonance imaging (MRI), and to correlate MRI indices of disease progression with classic inflammatory parameters and histologic evaluation. Methods. AIA was established in male Lewis rats following subcutaneous injection in the right hindpaw with 0.5 mg of heat-killed Mycobacterium butyricum suspended in light mineral oil. In vivo MRI evaluations of soft tissue and bony changes in AIA rats with matched histopathology were correlated with changes in left hindpaw volumes, circulating leukocytes, acutephase reactants, and urinary collagen crosslinks throughout the disease process. Results. MRI of arthritic tibiotarsal joints of the uninjected left hindpaws from AIA rats demonstrated 2 distinct phases of disease activity. The first phase, apparent between days 10 and 18, was characterized by periarticular inflammation with marked synovitis, synovial fibroplasia, and distension of the joint capsule into the surrounding tissue. The secondary phase, occurring between days 18 and 30, was marked by continued soft tissue inflammation, periostitis with osteolysis, and periosteal new bone

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Author

Peer B. Jacobson; Sheryl J. Morgan; Denise M. Wilcox; Phong Nguyen; Christine A. Ratajczak; Richard P. Carlson; Richard R. Harris; Merrill Nuss

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

1999

Language

EN

Field

Medicine (Health Sciences)